Can We Find Better Bronchodilators to Relieve Asthma Symptoms?

Can We Find Better Bronchodilators to Relieve Asthma Symptoms?

Bronchodilators are the first line therapy during acute asthmatic exacerbations to reverse airway obstruction primarily by relaxing airway smooth muscle. Only three categories of bronchodilators exist in clinical practice: β-adrenergic agonists, anticholinergics, and methylxanthines. Each of these categories have specific drugs dating back to the early 20th century, raising the question of whet...

Safety of bronchodilators and corticosteroids for asthma during pregnancy: what we know and what we need to do better

Asthma is a common medical condition complicating pregnancy with potentially serious effects on pregnancy outcome. The aim of this review is to provide an update on efficacy and safety of asthma medications, primarily bronchodilators and corticosteroids, used during pregnancy with focus on pregnancy outcome, and, furthermore, to discuss limitations of available studies and point to possible imp...

Restorative resection of radiation rectovaginal fistula can better relieve anorectal symptoms than colostomy only

BACKGROUND Radiation-induced rectovaginal fistula (RVF) is a severe and difficult complication after pelvic malignancy radiation. This study was to retrospectively compare the outcomes of restorative resection and colostomy only in remission of anorectal symptoms. METHODS We enrolled a cohort of 26 consecutive cases who developed RVF after pelvic radiation. Two main procedures for these patie...

We must--and we can--do better.

Burst Remnants : How can we find them ?

By now there is substantial evidence that Gamma-Ray Bursts (GRBs) originate at cosmological distances from very powerful explosions. The interaction between a GRB and its surrounding environment has dramatic consequences on the environment itself. At early times, the strong X-ray UV afterglow flux photoionizes the medium on distance scales on the order of 100 pc [7], destroys dust [10], creates...